BDBM22914 CHEMBL260374::N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide::Thioperamide::US11622967, Compound Thioperamide
SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
InChI Key InChIKey=QKDDJDBFONZGBW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 47 hits for monomerid = 22914
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 27nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 27nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 43nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 43nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 48nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 50.1nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by li...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63nMAssay Description:Displacement of clobenpropit-BODIPY-630/650 from recombinant human NLuc-fused H4R expressed in HEK293T cells by Nano-BRET assayMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 63.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 66nMAssay Description:Inhibition of UR-DEBa242 binding to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Displacement of UR-DEBa176 from mouse recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 79nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranesMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 124nMAssay Description:Displacement of [3H]histamine form human H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 125nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 minsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 126nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 126nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 126nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 155nMAssay Description:Inhibition of UR-DEBa242 binding to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate b...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 178nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 328nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 427nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Gai2 and Gb1c2 subunitMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R expressed in HEK293T cell homogenatesMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of UR-DEBa176 from human recombinant H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes c...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell homogenatesMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranes co...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-histamine from human recombinant H4R stably expressed in human SK-N-MC cell membranesMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 79.4nMAssay Description:Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by l...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 110nMAssay Description:Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 680nMAssay Description:Antagonist activity at human H4 receptor expressed in 293-EBNA cells assessed as inhibition of histamine agonist activity by luciferase reporter gene...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 417nMAssay Description:Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 667nMAssay Description:Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 977nMAssay Description:Antagonist activity at human H4 receptor expressed in HEK293T cells assessed as inhibition of histamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 110nMAssay Description:Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 120nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
The R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 490nMAssay Description:Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced ...More data for this Ligand-Target Pair
Affinity DataEC50: 302nMAssay Description:Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-...More data for this Ligand-Target Pair